Mixed-Composite-Type Equations as a Model of Anomalous Diffusion in Tumor Tissues
DOI:
https://doi.org/10.71310/pcam.2_72.2026.02Keywords:
Green’s function, potential, Jordan arc, mixed type equation, Lipschitz condition, biomedicine, oncology, tumor, anisotropyAbstract
This paper examines a boundary value problem for a degenerate elliptic equation in a planar domain bounded by a line segment and an analytic curve. The primary objective is to construct an explicit analytical solution using the Green’s function together with singleand double-layer potential methods. A rigorous proof of the existence and uniqueness of the solution under mixed boundary conditions is presented. The degeneracy on a portion of the boundary introduces significant analytical difficulties, necessitating the use of advanced techniques in the theory of elliptic equations with singular coefficients. Furthermore, the potential applications of the model in biomedical settings, particularly in oncology, are discussed. The equation captures anomalous diffusion processes in tumor tissues, incorporating the spatial heterogeneity of the medium. This makes the model a valuable tool for analyzing the distribution of drugs, oxygen, and other substances in biological structures characterized by pronounced anisotropy and heterogeneity.
References
Bitsadze A.V., Salakhitdinov M.S. On the theory of equations of mixed-composite type // Siberian Mathematical Journal. – 1961. – Vol. 2. – No. 1. – P. 7-19.
Islomov B.I., Ochilova N.K., Sadarangani K.S. On a Frankl-type boundary value problem for a mixed-type degenerating equation // Ukrainian Mathematical Journal. – 2019. – Vol. 71. – P. 1347-1359.
Islomov B.I., Usmonov B. Nonlocal boundary value problem for a third-order equation of elliptic-hyperbolic type // Lobachevskii Journal of Mathematics – 2020. – Vol. 41. – No. 1. – P. 32-38.
Abdullaev O.K. On a problem for the degenerating parabolic-hyperbolic equation involving Caputo derivative of fractional order and non-linear terms // Uzbek Mathematical Journal. – 2021. – No. 2. – P. 5-16.
Yuldashev T.K., Islomov B.I., Alikulov E.K. Boundary value problems for a loaded parabolic-hyperbolic equation in infinite three-dimensional domains of third order // Lobachevskii Journal of Mathematics – 2020. – Vol. 41. – No. 5. – P. 926-944.
Ochilova N.K., Yuldashev T.K. On a nonlocal boundary value problem for a degenerate parabolic-hyperbolic equation with fractional derivative // Lobachevskii Journal of Mathematics. – 2022. – Vol. 43. – No. 1. – P. 229-236.
Chanillo S., Wheeden R.L. Existence and estimates of Green's function for degenerate elliptic equations // Annali della Scuola Normale Superiore di Pisa – 1988. – Vol. 15. – No. 2. – P. 309-340.
Vishik M.I., Grushin V.V. On a class of higher order degenerate elliptic equations // Sbornik Mathematics. – 1969. – Vol. 9. – No. 4. – P. 423-454.
Levendorskii S.Z. Degenerate elliptic equations and boundary problems // Springer Lecture Notes in Mathematics. – 1992. – Vol. 1505. – P. 25-47.
Drábek P. Solvability of degenerate elliptic problems of higher order via Leray–Schauder degree // Hiroshima Mathematical Journal. – 1996. – Vol. 26. – Issue 1. – P. 1-14.
Beisebay P., Berdyshev A., Omarov B. Smoothness of the solution of a boundary value problem for degenerate elliptic equations // Symmetry. – 2025. – Vol. 17. – No. 9. – 1145.
Baishemirov Z., Berdyshev A., Ryskan A. A solution of a boundary value problem with mixed conditions for a four-dimensional degenerate elliptic equation // Mathematics. – 2022. – Vol. 10. – No. 7. – 1094.
Zhang G. The Kato problem and extensions for degenerate elliptic operators of higher order in weighted spaces // arXiv preprint arXiv:2511.04046. – 2025.
Irgashev B.Yu. Boundary value problem for a degenerate high-order equation with discontinuous coefficients // Uzbek Mathematical Journal. – 2021. – Vol. 65. – No. 4. – P. 13-26.
Pankov V.V., Baev A.D., Kharchenko V.D. A priori estimate of solutions of one boundary-value problem in a strip for a higher-order degenerate elliptic equation // Journal of Mathematical Sciences – 2022. – Vol. 264. – P. 452-463.
Ergashev T.G. Potentials for singular elliptic equations and their applications // Russian Mathematics (Izvestiya VUZ. Matematika). – 2009. – Vol. 53. – No. 8. – P. 46-57.
Le V.K. On boundary value problems for degenerate quasilinear elliptic equations of higher order // Nonlinear Analysis. – 1998. – Vol. 31. – No. 3. – P. 441-456.
Pukal'skii I.D., Yashan B.O. Optimal control in the boundary value problem for elliptic equations with degeneration // Mathematical Studies. – 2023. – Vol. 60. – No. 2. – P. 45-58.
Barton A. Boundary-value problems for higher-order elliptic equations // Higher-Order Elliptic Equations and Systems. Springer. – 2013. – P. 99-122.
Mukhamedov A., Yusupov F.A. Analysis of some boundary value problems for mixed-type equations with two lines of degeneracy // Irish Interdisciplinary Journal of Science and Research. – 2022. – Vol. 6. – No. 2. – P. 87-96.
Witt I. A calculus for a class of finitely degenerate pseudodifferential operators // Banach Center Publications. – 2003. – Vol. 60. – P. 295-317.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Н.К. Очилова

This work is licensed under a Creative Commons Attribution 4.0 International License.